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Discussion On Drug-Metabolism Enzyme
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Discussion On Drug-Metabolism Enzyme
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Question:
How do enzyme kinetics affect an individuals response to therapeutic and other drugs.
Answer:
One can call the drug-metabolism enzyme as the “mixed function oxidase”, or the “mono-oxygenase” (Bishop, Fody & Schoeff, 2013). The particular enzyme contains the “cytochrome P450”. Along with it, the particular enzyme contains the “cytochrome b5”. Other than these components, components like “NADPH-cytochrome P450 reductase”, along with other components are included in it at the same time. The CY or the “hepatic cytochrome P450s” belongs to a multi-gene family and thus plays an important role in the process of metabolism (Zanger & Schwab 2013).
References
Bishop, M. L., Fody, E. P., & Schoeff, L. E. (Eds.). (2013). Clinical Chemistry: Principles, Techniques, and Correlations. Lippincott Williams & Wilkins.
Zanger, U. M., & Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & therapeutics, 138(1), 103-1
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